Biolas VariClose is an embolization polymer that is indicated for “ablation by polymerization” of saphenous vein (vena saphena magna, valve saphenous parva) or perforator veins in Endovenous treatment of incompetent lower extremity varicose veins.
Biolas VariClose vein sealing system combines a simple procedure technique with an efficient ablation method. Physician only needs an ultrasound guidance to perform the procedure, without the necessity of surgery room, in clinic within several minutes.

VariClose offers advantages such as ease of use, shortening of the procedure time, perform in outpatient conditions, eliminating the necessity of tumescent anesthesia in thermal ablation and prevention from complications in thermal ablation (nerve damage, hematoma, rush, burn and etc.).

PDF Literature Order in File Article / Name Years / Mounth Link
2 A prospective comparison of a new cyanoacrylate glue and laser ablation for the treatment of venous insufficiency 2016 Mar 
3 Early-Term Outcomes for Treatment of Saphenous Vein Insufficiency with N-Butyl Cyanoacrylate: A Novel, Non-Thermal, and Non-Tumescent Percutaneous Embolization Technique 2016 Jun 
9 Endovascular treatment of arterial access site injuries with N-butyl cyanoacrylate embolization 2016 Sep 
7 Non Thermal, Non Tumescent Endovenous Treatment of Varicose Veins 2016 Oct 
6 N-butyl cyanoacrylate in the treatment of venous insufficiency--the effect of embolisation with ablative polymerisation 2016 
11 A Comparison Of Mini-incisional Ligation, Laser Ablation And Cyanoacrylate Embolization For Incompetent Perforating Vein Closure 2016 
1 Ablation of the great saphenous vein with nontumescent n-butyl cyanoacrylate versus endovenous laser therapy 2017 Jan  2017 Jan  
5 Sclerotherapy and Vein Gluing Combined as a Single-Catheter Procedure for Saphenous Veins 2017 Jan 
4 A new non-tumescent endovenous ablation method for varicose vein treatment: Early results of N-butyl cyanoacrylate (VariClose) 2017 Apr 
8 Predictors of Recanalization for
Incompetent Great Saphenous Veins
Treated with Cyanoacrylate Glue
2017 May 
10 Pilot study of the use of cyanoacrylate in the treatment of varicose veins 2017  
  • VariClose® eliminates the necessity of “tumescent anesthesia” in thermal endovenous ablation methods
  • No need for general or spinal anesthesia
  • Easy to use compared to the different endovenous techniques
  • Eliminates numbness, skin and nerve damage complications that caused by thermal ablation methods
  • Provides immediate results after procedure
  • Short procedure time
  • No need for surgery room conditions
  • Patients can return their work and daily routines immediately

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